She had performed previously with Jack White and Jack Lawrence and The Raconteurs, prior to this band's formation. She co-wrote (with Dean Fertita) the band's first single "Hang You from the Heavens" which was released on March 11, 2009.
Mosshart also wrote So Far From Your Weapon and co-wrote eight of the original ten tracks on their debut album Horehound.
In 2003, The Kills released their first album Keep on Your Mean Side.
In 2005, they released their follow-up album No Wow.
People say that the performances are kind of like watching a private conversation—and we haven’t played a show in a while. Do you think it was harder for Jamie since, at the same time, he’s gained this notoriety for something besides music? Sometimes that gets more attention than the actual music; the progression from album to album. “The Kills are too cool.” There’s been an on-and-off relationship with the music press that loves us and then hates us then loves us again.
Mosshart joined White to perform White's song "Love Interruption", and both Mosshart and Hince joined White to perform Leadbelly's "Goodnight Irene".Four years since I don’t think any kind of break can fuck with 11 and a half years, you know? It’s a show and I’m a performer and an artist and I’m not just gonna show up in sweat pants If I were going to do a book on The Kills and hired a photo researcher to delve into your past, would I find a photo of you in sweat pants? He was listening to a lot of Roxy Music and Grace Jones, and I was just surrounded by that Southern blues world. But I didn’t see him for a month at a time or two months at a time. In 2010, a second album - Sea of Cowards - was released.The lead single, Die By The Drop, was written by Mosshart, Fertita, and Lawrence.